Maleylacetoacetate Isomerase

Preferred Label : Maleylacetoacetate Isomerase;

NCIt synonyms : Glutathione S-Transferase Zeta 1; Maleylacetone Isomerase; Glutathione Transferase Zeta 1; EC 2.5.1.18; MAAI; EC 5.2.1.2; GSTZ1; Glutathione S-Transferase Zeta-1; GSTZ1-1;

NCIt definition : Maleylacetoacetate isomerase (216 aa, 24 kDa) is encoded by the human GSTZ1 gene. This protein is involved in catalyzing both the isomerization of maleylacetoacetate forming fumarylacetoacetate and the glutathione-dependent oxygenation of dichloroacetic acid to form glyoxylic acid.;

NCIt note : Maleylacetoacetate isomerase exhibits minimal glutathione-conjugating and glutathione peroxidase activities. (UniProt);

Details

Origin ID

C199334;

OMIM relation
- Glutathione s-transferase, zeta-1 [OMIM gene]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GSTZ1 Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_biochemical_function
- Glutathione S-Transferase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Phenylalanine Metabolism Pathway [NCIt concept]
- Tyrosine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biogenic Amine Metabolic Process [NCIt concept]
- Drug Metabolism [NCIt concept]

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