" /> CYP2D6*41 Allele - CISMeF





Preferred Label : CYP2D6*41 Allele;

NCIt synonyms : CYP2D6, R296C, S486T; CYP2D6*41; Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*41 Allele; CYP2D6, g.2850C T, g.4180G C; CYP2D6 41 Allele;

NCIt definition : Human CYP2D6*41 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*41 protein. The CYP2D6*41 allele exhibits clinically-relevant SNPs (g.2850C T; g.4180G C) in exons 6 and 9 that result in R296C and S486T coding changes. These alterations in protein sequence decrease the enzymatic activity of the cytochrome P450 2D6*41 protein.;

NCIt note : Ethnicity Association: African American; Caucasian;

GenBank Accession Number : NM_000106;

PubMed : 11037799; 15768052; 15289790;

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20/05/2024


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