" /> CYP2C8*2 Allele - CISMeF





Preferred Label : CYP2C8*2 Allele;

NCIt synonyms : CYP2C8*2; CYP2C8, I269F; CYP2C8, c.805A T; Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*2 Allele; CYP2C8 2 Allele;

NCIt definition : Human CYP2C8*2 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*2 protein. The CYP2C8*2 allele exhibits a clinically-relevant SNP (c.805A T) in exon 5 that results in an I269F coding change. This sequence alteration in the cytochrome P450 2C8*2 protein increases the Km of this enzyme for paclitaxel, thereby decreasing the clearance of this drug.;

NCIt note : Ethnicity Association: African American;

GenBank Accession Number : NM_000770;

SNP ID : rs11572103;

PubMed : 11668219;

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24/04/2024


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