" /> CYP2D6*21 Allele - CISMeF





Preferred Label : CYP2D6*21 Allele;

NCIt synonyms : CYP2D6*21; Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*21 Allele; CYP2D6, g.2573insC; CYP2D6 21 Allele;

NCIt definition : Human CYP2D6*21 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*21 protein. The CYP2D6*21 allele exhibits a single nucleotide insertion (g.2573insC) in exon 5 that results in a frameshift and generates a stop codon 17 bp downstream of the insertion site. This alteration abolishes the enzymatic activity of the cytochrome P450 2D6*21 protein.;

NCIt note : Ethnicity Association: Asian;

GenBank Accession Number : NM_000106;

PubMed : 10471060;

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20/05/2024


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