UDP-Glucuronosyltransferase 1-1

Preferred Label : UDP-Glucuronosyltransferase 1-1;

NCIt synonyms : Bilirubin Specific UDPGT Isozyme 1; UDPGT; EC 2.4.1.17; HUG-BR1; UGT1A; UDP-Glucuronosyltransferase 1A1; UGT1A1; UDP-Glucuronosyltransferase 1-A; UGT1-01; UDPGT 1-1; UGT1A1 Protein; UGT1*1; UGT-1A; UGT1.1; Bilirubin UDP-Glucuronosyltransferase; Bilirubin UDP-Glucuronosyltransferase Isozyme 1; Bilirubin UDP-Glucuronosyltransferase 1-1;

NCIt definition : UDP-glucuronosyltransferase 1-1 (533 aa, 60 kDa) is encoded by the human UGT1A1 gene. This protein is involved in the glucuronidation of bilirubin, simple phenols, flavones, and C18 steroids.;

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It is an enzyme produced by the liver and intestine.;

Codes from synonyms : CDR0000269429;

Details

Origin ID

C28288;

UMLS CUI

C1567723;

OMIM relation
- Udp-glycosyltransferase 1 family, polypeptide a1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- UGT1A1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Glycosyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- UGT1A1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ascorbate and Aldarate Metabolism Pathway [NCIt concept]
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Pentose and Glucuronate Interconversions Pathway [NCIt concept]
- Porphyrin and Chlorophyll Metabolism Pathway [NCIt concept]
- Retinol Metabolism Pathway [NCIt concept]
- Starch and Sucrose Metabolism Pathway [NCIt concept]
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Estrogen Metabolic Process [NCIt concept]
- Glycosylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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