Cholesterol 7-Alpha-Monooxygenase

Preferred Label : Cholesterol 7-Alpha-Monooxygenase;

NCIt synonyms : Cytochrome P450 Family 7 Subfamily A Polypeptide 1; Cytochrome P450 Subfamily VIIA (Cholesterol 7 Alpha-Monooxygenase) Polypeptide 1; CYP7A1; CYPVII; Cholesterol 7 Alpha-Monooxygenase; Cholesterol 7-Alpha-Hydroxylase; Cytochrome P450 7A1; EC 1.14.13.17; Cytochrome P450, Subfamily VIIA (Cholesterol 7 Alpha-Monooxygenase), Polypeptide 1; Cytochrome P450, Subfamily VIIA Polypeptide 1; Cytochrome-P450-7A1;

NCIt definition : Cholesterol 7-alpha-monooxygenase (504 aa, 58 kDa) is encoded by the human CYP7A1 gene. This protein plays a role in both cholesterol catabolism and bile acid biosynthesis.;

Details

Origin ID

C40053;

UMLS CUI

C2976704;

Currated CISMeF NLP mapping
- cholesterol 7-alpha-Hydroxylase [MeSH concept]
- cholesterol 7-alpha-hydroxylase [MeSH Descriptor]
OMIM relation
- Cytochrome p450, subfamily viia, polypeptide 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CYP7A1 protein, human [MeSH concept]
- CYP7A1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CYP7A1 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bile Acid Biosynthesis Pathway [NCIt concept]
- PPAR Signaling Pathway [NCIt concept]
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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