Bile Acid Biosynthesis Pathway

Preferred Label : Bile Acid Biosynthesis Pathway;

NCIt related terms : Primary bile acid biosynthesis; Bile Acid Biosynthesis;

Alternative definition : KEGG: Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine.;

NCI Metathesaurus CUI : CL020725;

KEGG ID : hsa00120;

Details

Origin ID

C38789;

UMLS CUI

C1157403;

Currated CISMeF NLP mapping
- bile acid biosynthetic process [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- bile acid biosynthetic process [GO term]
has_gene_product_element
- 24-Hydroxycholesterol 7-Alpha-Hydroxylase [NCIt concept]
- 25-Hydroxycholesterol 7-Alpha-Hydroxylase [NCIt concept]
- 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2 [NCIt concept]
- 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase [NCIt concept]
- Alpha-Methylacyl-CoA Racemase [NCIt concept]
- Cholesterol 25-Hydroxylase [NCIt concept]
- Cholesterol 7-Alpha-Monooxygenase [NCIt concept]
- Peroxisomal Acyl-Coenzyme A Oxidase 2 [NCIt concept]
- Peroxisomal Multifunctional Enzyme Type 2 [NCIt concept]
pathway_has_gene_element
- ACOX2 wt Allele [NCIt concept]
- AMACR wt Allele [NCIt concept]
- CH25H wt Allele [NCIt concept]
- CYP39A1 wt Allele [NCIt concept]
- CYP7A1 wt Allele [NCIt concept]
- CYP7B1 wt Allele [NCIt concept]
- CYP8B1 wt Allele [NCIt concept]
- HSD17B4 wt Allele [NCIt concept]
- SRD5A2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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