3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2

Preferred Label : 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2;

NCIt synonyms : Steroid 5-Alpha-Reductase 2; EC 1.3.99.5; Type II 5-Alpha Reductase; SR Type 2; SRD5A2; Steroid 5 Alpha-Reductase 2; 5 Alpha-SR2; Steroid 5-Alpha-Reductase-2;

NCIt definition : 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (254 aa, 28 kDa) is encoded by the human SRD5A2 gene. This protein plays a role in sexual differentiation and androgen metabolism.;

NCIt note : This enzyme catalyzes the reduction of testosterone to 5 alphadihydrotestosterone.;

Details

Origin ID

C17190;

UMLS CUI

C2933072;

OMIM relation
- Steroid 5-alpha-reductase 2 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase [MeSH Descriptor]
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase [MeSH concept]
- 3-oxo-5alpha-steroid delta4-dehydrogenase [SNOMED Notion]
- Cholestenone 5alpha-reductase (substance) [SNOMED CT concept]
- SRD5A2 protein, human [MeSH Supplementary Concept]
- SRD5A2 protein, human [MeSH concept]
- cholestenone 5alpha-reductase [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
- SRD5A2 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Prostate Gland [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Steroid 5 Alpha-Reductase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bile Acid Biosynthesis Pathway [NCIt concept]
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Prostate Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Androgen Metabolism Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Dutasteride [NCIt concept]
- Finasteride [NCIt concept]

Keyword's position in hierarchy(ies) :

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