Preferred Label : Dutasteride;
NCIt synonyms : Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide;
NCIt related terms : GG745; Avodart;
NCIt definition : A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds
to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting
the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction
in DHT activity may mitigate or prevent enlargement of the prostate gland. The type
2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while
the type 1 isoenzyme is also active in skin and the liver.;
Alternative definition : NCI-GLOSS: A drug used to treat symptoms of an enlarged prostate gland. It is being
studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes
the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor.;
UNII : O0J6XJN02I;
InChIKey : JWJOTENAMICLJG-QWBYCMEYSA-N;
CAS number : 164656-23-9;
Drug name : Avodart;
Molecule name : GG 745;
Chemical formula : C27H30F6N2O2;
ChEBI ID : CHEBI:521033;
Codes from synonyms : CDR0000523321; CDR0000488413; 50531; CDR0000523319; 174;
Origin ID : C47503;
UMLS CUI : C0754659;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
