3-Oxo-5-alpha-Steroid 4-Dehydrogenase

Preferred Label : 3-Oxo-5-alpha-Steroid 4-Dehydrogenase;

MeSH definition : An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE.;

MeSH synonym : delta-4-5-alpha-reductase, testosterone; 4 ene 3 oxosteroid 5alpha reductase; 4 ene 5 alpha reductase; testosterone delta-4-5-alpha-reductase; 5-alpha-reductase, testosterone; nadh-5-alpha-reductase; testosterone 5 alpha reductase; 4-ene-3-oxosteroid-5alpha-reductase; 4-ene-5-alpha-reductase; delta(4)-3-ketosteroid-5alpha-reductase; nadh 5 alpha reductase; steroid 5alpha reductase; 5alpha reductase, steroid; reductase, steroid 5alpha; steroid delta-4-5-alpha reductase; reductase, steroid delta-4-5-alpha; steroid delta 4 5 alpha reductase; delta-4-5-alpha reductase, steroid; 5 alpha reductase, testosterone; testosterone delta 4 5 alpha reductase; 3-keto-5-alpha-steroid delta-4-dehydrogenase; 3 keto 5 alpha steroid delta 4 dehydrogenase; delta-4-dehydrogenase, 3-keto-5-alpha-steroid; nadph delta(4)-3-ketosteroid 5 alpha-oxidoreductase; steroid 5-alpha-Reductase; 5-alpha-Reductase, steroid; steroid 5 alpha reductase; testosterone 5-alpha-Reductase; 3 oxo 5 alpha steroid 4 dehydrogenase; 3-oxo-5alpha-Steroid 4-Dehydrogenase (NADP ); 3-oxo-5 alpha-Steroid 4-Dehydrogenase (NADP ); delta 4-3-keto Steroid 5 alpha-Oxidoreductase; delta 4 3 keto Steroid 5 alpha Oxidoreductase; delta4-3-ketosteroid 5alpha-Oxidoreductase; 5alpha-Oxidoreductase, delta4-3-ketosteroid; delta4 3 ketosteroid 5alpha Oxidoreductase;

CISMeF synonym : 4-reductase, delta; delta 4-reductase; delta 4 reductase; srd5a2;

MeSH CAS label : 3-Oxo-5 alpha-steroid:(acceptor) delta(4)-oxidoreductase;

Registry Number MeSH : EC 1.3.99.5;

Is substance : O;

UNII : EC 1.3.99.5;

Details

Origin ID

D013741;

UMLS CUI

C0039602;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2 [NCIt concept]
- 3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO term]
- Cholestenone 5alpha-reductase (substance) [SNOMED CT concept]
- SRD5A2 Gene [NCIt concept]
- Steroid 5 Alpha-Reductase [NCIt concept]
- Steroid 5-alpha-reductase 2 [OMIM gene]
- cholestenone 5-alpha-reductase activity [GO term]
- steroid 5 alpha-reductase 2 [ORDO Gene]
- steroid 5 alpha-reductase 3 [HGNC gene]
Indexing information
- (22RS-N-1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide [MeSH Supplementary Concept]
- (5alpha)-23-methyl-4-aza-21-norchol-1-ene-3,20-dione [MeSH Supplementary Concept]
- 17-(N,N,-diisopropylcarbamoyl)androst-3,5-diene-3-carboxylic acid [MeSH Supplementary Concept]
- 17-(N,N-diisopropylcarbamoyl)estra-1,3,5(10)-triene-3-sulfonic acid [MeSH Supplementary Concept]
- 17-(N,N-diisopropylcarboxamide)estra-1,3,5(10)-triene-3-carboxylic acid [MeSH Supplementary Concept]
- 17-(N-t-butylcarboxamide)estra-1,3,5(10)-triene-3-carboxylic acid [MeSH Supplementary Concept]
- 17-N,N-diisopropylcarbamoyl-4-azaandrostan-3-one [MeSH Supplementary Concept]
- 17-acetoxy-6-methylene-4-pregnene-3,20-dione [MeSH Supplementary Concept]
- 17-p-bromophenylcarbamoyloxypregn-4-ene-3,20-dione [MeSH Supplementary Concept]
- 17-phenylcarbamoyloxypregn-4-ene-3,20-dione [MeSH Supplementary Concept]
- 2,3,5,6-tetrahydro-4,8-dimethylbenzo(c)quinolizin-3-one [MeSH Supplementary Concept]
- 2-hydroxynonafluoroazobenzene [MeSH Supplementary Concept]
- 20-(hydroxymethyl)-4-methyl-4-aza-2-oxapregnan-3-one [MeSH Supplementary Concept]
- 3'-geranyl-2',3,4,4'-tetrahydroxychalcone [MeSH Supplementary Concept]
- 4-hydroxynonafluoroazobenzene [MeSH Supplementary Concept]
- 4-methoxyandrostenedione [MeSH Supplementary Concept]
- 4-methyl-benzo(c)quinolizin-3-one [MeSH Supplementary Concept]
- 6 beta methoxy-9 beta,10 alpha-pregna-4,6-dien-3,20-dione [MeSH Supplementary Concept]
- 8-allyl-7-hydroxy-2H-benzopyran-2-one [MeSH Supplementary Concept]
- 8-chloro-2,3,5,6-tetrahydro-4-methylbenzo(c)quinolizin-3-one [MeSH Supplementary Concept]
- DET2 protein, arabidopsis [MeSH Supplementary Concept]
- FCE 27837 [MeSH Supplementary Concept]
- FCE 28175 [MeSH Supplementary Concept]
- L 685273 [MeSH Supplementary Concept]
- N,N-diethyl-3-oxo-4-azaandrost-1-ene-17-carboxamide [MeSH Supplementary Concept]
- N,N-diethyl-4-methoxy-3-oxo-4-aza-5-androstene-17-carboxamide [MeSH Supplementary Concept]
- N-(1',1'-dimethylethyl)-3-fluoroandrost-3,5-dien-17-carboxamide [MeSH Supplementary Concept]
- N-(1-(4-trifluoromethylphenyl)cyclopentenyl)-3-oxo-4-aza-5a-androst-1-ene-17beta-carboxamide [MeSH Supplementary Concept]
- N-ethyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide [MeSH Supplementary Concept]
- SNA 4606-1 [MeSH Supplementary Concept]
- SPET 085 [MeSH Supplementary Concept]
- WS 9659 B [MeSH Supplementary Concept]
- Z 350 [MeSH Supplementary Concept]
- testosterone formate [MeSH Supplementary Concept]
Record concept(s)
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase [MeSH concept]
Related MeSH Supplementary Concept(s)
- SRD5A1 protein, human [MeSH Supplementary Concept]
- SRD5A2 protein, human [MeSH Supplementary Concept]
- SRD5A3 protein, human [MeSH Supplementary Concept]
- Srd5a1 protein, mouse [MeSH Supplementary Concept]
- Srd5a1 protein, rat [MeSH Supplementary Concept]
- Srd5a2 protein, mouse [MeSH Supplementary Concept]
- Srd5a2 protein, rat [MeSH Supplementary Concept]
- Srd5a3 protein, mouse [MeSH Supplementary Concept]
- pseudovaginal perineoscrotal hypospadias [MeSH Supplementary Concept]
- steroid-5alpha-reductase type 1 [MeSH Supplementary Concept]
- steroid-5alpha-reductase type 2 [MeSH Supplementary Concept]
Related MeSH term(s)
- 5-alpha reductase inhibitors [MeSH Descriptor]
See also
- adrenal hyperplasia, congenital [MeSH Descriptor]
See also (suggested by CISMeF)
- 5-alpha reductase inhibitors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2 [NCIt concept]
- 3-oxo-5alpha-steroid delta4-dehydrogenase [SNOMED Notion]
- Cholestenone 5alpha-reductase (substance) [SNOMED CT concept]
- Steroid 5 Alpha-Reductase [NCIt concept]
- cholestenone 5alpha-reductase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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