Peroxisomal Multifunctional Enzyme Type 2

Preferred Label : Peroxisomal Multifunctional Enzyme Type 2;

NCIt synonyms : 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholest-24-Enoyl-CoA Hydratase; Multifunctional Protein 2; MFE-2; D-3-Hydroxyacyl-CoA Dehydratase/D-3-Hydroxyacyl-CoA Dehydrogenase Bifunctional Protein; 17-Beta-HSD 4; Beta-Hydroxyacyl Dehydrogenase; Beta-Keto-Reductase; Short Chain Dehydrogenase/Reductase Family 8C, Member 1; 17beta-Estradiol Dehydrogenase Type IV; 17-Beta-Hydroxysteroid Dehydrogenase 4; 17-Beta-HSD IV; D-3-Hydroxyacyl-CoA Dehydratase; D-Bifunctional Protein, Peroxisomal; DBP; DBP, Peroxisomal; MPF-2; Peroxisomal Multifunctional Protein 2; HSD17B4;

NCIt definition : Peroxisomal multifunctional enzyme type 2 (736 aa, 80 kDa) is encoded by the human HSD17B4 gene. This protein is involved in the peroxisomal beta-oxidation pathway for fatty acids.;

NCIt note : Peroxisomal multifunctional enzyme type 2 is cleaved into two chains with the following enzymatic activities: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) and enoyl-CoA hydratase 2 (EC 4.2.1.107 and EC 4.2.1.119, also called 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase). (UniProt);

Details

Origin ID

C114366;

UMLS CUI

C0536221;

Automatic exact mappings (from CISMeF team)
- 17-beta-hydroxysteroid dehydrogenase iv [OMIM gene]
- 3-Hydroxyacyl CoA dehydrogenases [MeSH Descriptor]
- 3-Hydroxyacyl-CoA dehydrogenase [MeSH Descriptor]
- 3-hydroxyacyl-coenzyme A dehydrogenase (substance) [SNOMED CT concept]
- D-3-hydroxyacyl CoA dehydratase [MeSH concept]
- D-3-hydroxyacyl CoA dehydratase [MeSH Supplementary Concept]
- D-box-binding par bzip transcription factor [OMIM gene]
- Group-specific component [OMIM Phenotype]
- Group-specific component [OMIM gene]
- biliopancreatic diversion [MeSH Descriptor]
- bronchopulmonary dysplasia [MeSH Descriptor]
- enoyl-CoA hydratase activity [GO term]
- hydroxysteroid 17-beta dehydrogenase 4 [ORDO Gene]
- hydroxysteroid 17-beta dehydrogenase 4 [HGNC gene]
- peroxisomal multifunctional Protein-2 [MeSH Descriptor]
- peroxisomal multifunctional Protein-2 [MeSH concept]
OMIM relation
- 17-beta-hydroxysteroid dehydrogenase iv [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HSD17B4 protein, human [MeSH Supplementary Concept]
- HSD17B4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HSD17B4 Gene [NCIt concept]
- Lyase Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Peroxisome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bile Acid Biosynthesis Pathway [NCIt concept]
- Peroxisome Biogenesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Fatty Acid Metabolism [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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