peroxisomal multifunctional Protein-2

Preferred Label : peroxisomal multifunctional Protein-2;

MeSH definition : A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.;

MeSH synonym : multifunctional Protein-2, peroxisomal; peroxisomal multifunctional protein 2; 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA hydratase; peroxisomal multifunctional enzyme type 2; 17-beta-Hydroxysteroid dehydrogenase 4; 17 beta hydroxysteroid dehydrogenase 4; 4, 17-beta-Hydroxysteroid dehydrogenase; dehydrogenase 4, 17-beta-Hydroxysteroid;

MeSH Related Number : EC 1.1.1.-; EC 4.2.1.119;

Registry Number MeSH : EC 4.2.1.107;

Is substance : O;

UNII : EC 4.2.1.107;

Details

Origin ID

D064029;

UMLS CUI

C3539825;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
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- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- peroxisomal multifunctional Protein-2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- HSD17B4 protein, human [MeSH Supplementary Concept]
- Hsd17b4 protein, mouse [MeSH Supplementary Concept]
- Hsd17b4 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

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