7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase

Preferred Label : 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase;

NCIt synonyms : 7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase; Cytochrome P450 Family 8 Subfamily B Polypeptide 1; Sterol 12 Alpha Hydroxylase; Steroid 12-Alpha-Hydroxylase; CYP8B1; CYPVIIIB1; Cytochrome P450 CYP8B1; Cytochrome P450 Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase) Polypeptide 1; Cytochrome P450 8B1; EC 1.14.13.95; Sterol 12-Alpha-Hydroxylase; Cytochrome-P450-8B1;

NCIt definition : 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (501 aa, 58 kDa) is encoded by the human CYP8B1 gene. This protein is involved in bile acid biosynthesis and steroid metabolism.;

Details

Origin ID

C40055;

UMLS CUI

C1522546;

Currated CISMeF NLP mapping
- steroid 12-alpha-Hydroxylase [MeSH concept]
- steroid 12-alpha-hydroxylase [MeSH Descriptor]
OMIM relation
- Cytochrome p450, subfamily viiib, polypeptide 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- CYP8B1 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bile Acid Biosynthesis Pathway [NCIt concept]
- Lipid Metabolism and Toxicity Pathway [NCIt concept]
- PPAR Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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