PPAR Signaling Pathway

Preferred Label : PPAR Signaling Pathway;

NCIt synonyms : Peroxisome Proliferator-Activated Receptor Signaling Pathway;

Alternative definition : KEGG: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.;

KEGG ID : hsa03320;

Details

Origin ID

C91497;

UMLS CUI

C2752275;

Currated CISMeF NLP mapping
- peroxisome proliferator activated receptor signaling pathway [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- peroxisome proliferator activated receptor signaling pathway [GO term]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase [NCIt concept]
- Acyl-CoA Desaturase [NCIt concept]
- Adiponectin [NCIt concept]
- Angiopoietin-Related Protein 4 [NCIt concept]
- Apolipoprotein A-I [NCIt concept]
- Apolipoprotein A-II [NCIt concept]
- Apolipoprotein A-V [NCIt concept]
- Apolipoprotein C-III [NCIt concept]
- Carnitine O-Palmitoyltransferase 1, Brain Isoform [NCIt concept]
- Carnitine O-Palmitoyltransferase 1, Liver Isoform [NCIt concept]
- Carnitine O-Palmitoyltransferase 2, Mitochondrial [NCIt concept]
- Cholesterol 7-Alpha-Monooxygenase [NCIt concept]
- Fatty Acid-Binding Protein, Adipocyte [NCIt concept]
- Fatty Acid-Binding Protein, Heart [NCIt concept]
- Fatty Acid-Binding Protein, Intestinal [NCIt concept]
- Fatty Acid-Binding Protein, Liver [NCIt concept]
- Gastrotropin [NCIt concept]
- Integrin-Linked Protein Kinase [NCIt concept]
- Interstitial Collagenase [NCIt concept]
- Lipoprotein Lipase [NCIt concept]
- Long-Chain Fatty Acid Transport Protein 4 [NCIt concept]
- Long-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial [NCIt concept]
- Long-Chain-Fatty-Acid-CoA Ligase 1 [NCIt concept]
- Long-Chain-Fatty-Acid-CoA Ligase 3 [NCIt concept]
- Long-Chain-Fatty-Acid-CoA Ligase 6 [NCIt concept]
- Mitochondrial Brown Fat Uncoupling Protein 1 [NCIt concept]
- NADP-Dependent Malic Enzyme [NCIt concept]
- Peroxisomal Acyl-Coenzyme A Oxidase 1 [NCIt concept]
- Peroxisomal Acyl-Coenzyme A Oxidase 2 [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Alpha [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Delta [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Gamma [NCIt concept]
- Platelet Glycoprotein 4 [NCIt concept]
- Polyubiquitin-C [NCIt concept]
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Beta [NCIt concept]
- Retinoic Acid Receptor RXR-Gamma [NCIt concept]
pathway_has_gene_element
- ACADL wt Allele [NCIt concept]
- ACOX1 wt Allele [NCIt concept]
- ACOX2 wt Allele [NCIt concept]
- ACSL1 wt Allele [NCIt concept]
- ACSL3 wt Allele [NCIt concept]
- ACSL6 wt Allele [NCIt concept]
- ADIPOQ wt Allele [NCIt concept]
- ANGPTL4 wt Allele [NCIt concept]
- APOA1 wt Allele [NCIt concept]
- APOA2 wt Allele [NCIt concept]
- APOA5 wt Allele [NCIt concept]
- APOC3 wt Allele [NCIt concept]
- CD36 wt Allele [NCIt concept]
- CPT1A wt Allele [NCIt concept]
- CPT1C wt Allele [NCIt concept]
- CPT2 wt Allele [NCIt concept]
- CYP7A1 wt Allele [NCIt concept]
- CYP8B1 wt Allele [NCIt concept]
- FABP1 wt Allele [NCIt concept]
- FABP2 wt Allele [NCIt concept]
- FABP3 wt Allele [NCIt concept]
- FABP4 wt Allele [NCIt concept]
- FABP6 wt Allele [NCIt concept]
- ILK wt Allele [NCIt concept]
- LPL wt Allele [NCIt concept]
- ME1 wt Allele [NCIt concept]
- MMP1 wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PPARA wt Allele [NCIt concept]
- PPARD wt Allele [NCIt concept]
- PPARG wt Allele [NCIt concept]
- RXRA wt Allele [NCIt concept]
- RXRB wt Allele [NCIt concept]
- RXRG wt Allele [NCIt concept]
- SCD wt Allele [NCIt concept]
- SLC27A4 wt Allele [NCIt concept]
- UBC wt Allele [NCIt concept]
- UCP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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