Interstitial Collagenase

Preferred Label : Interstitial Collagenase;

NCIt synonyms : Fibroblast Collagenase; CLG; MMP1; EC 3.4.24.7; Matrix Metalloproteinase 1; Matrix Metalloprotease-1; MMP-1; Matrix Metalloproteinase-1; Matrix Metalloprotease 1;

NCIt definition : Interstitial collagenase (469 aa, 54 kDa) is encoded by the human MMP1 gene. This protein plays a role in collagenolysis.;

NCIt note : MMP1 preferentially cleaves interstitial collagens types I, II, and III at one site in the triple helical domain. MMP1 also cleaves collagens types VII and X and alpha-macroglobulins.;

Details

Origin ID

C41044;

UMLS CUI

C2001899;

Currated CISMeF NLP mapping
- matrix metalloproteinase 1 [MeSH Descriptor]
- matrix metalloproteinase 1 [MeSH concept]
OMIM relation
- Matrix metalloproteinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MMP1 protein, human [MeSH concept]
- MMP1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MMP1 Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Rebimastat [NCIt concept]
gene_product_has_biochemical_function
- Collagenase [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- Bladder Cancer Pathway [NCIt concept]
- PPAR Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Rebimastat [NCIt concept]

Keyword's position in hierarchy(ies) :

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