Peroxisome Proliferator-Activated Receptor Alpha

Preferred Label : Peroxisome Proliferator-Activated Receptor Alpha;

NCIt synonyms : Nuclear Receptor Subfamily 1 Group C Member 1; PPAR-Alpha; PPARA; NR1C1;

NCIt definition : Peroxisome proliferator-activated receptor alpha (468 aa, 52 kDa) is encoded by the human PPARA gene. This protein is involved in cell proliferation, transcriptional regulation and immunity.;

NCIt note : Peroxisome proliferator-activated receptor alpha interacts with hypolipidemic drugs and fatty acids.;

Details

Origin ID

C91751;

UMLS CUI

C4551616;

Currated CISMeF NLP mapping
- PPAR alpha [MeSH Descriptor]
- PPAR alpha [MeSH concept]
- Peroxisome proliferator-activated receptor-alpha [OMIM Phenotype]
OMIM relation
- Peroxisome proliferator-activated receptor-alpha [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- PPARA Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- GPCR Desensitization Pathway [NCIt concept]
- PGC1a Regulation Pathway [NCIt concept]
- PPAR Pathway [NCIt concept]
- PPAR Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Fatty Acid Metabolism [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- PPAR Alpha Antagonist TPST-1120 [NCIt concept]

Keyword's position in hierarchy(ies) :

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