steroid 12-alpha-hydroxylase

Preferred Label : steroid 12-alpha-hydroxylase;

MeSH definition : A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.;

MeSH synonym : alpha-hydroxylase, sterol 12; cyp8b1; cytochrome p450 cyp8b1; cytochrome p450 8b1; steroid 12 hydroxylase; steroid 12 monooxygenase; steroid 12-hydroxylase; steroid 12-monooxygenase; steroid-12-hydroxylase; steroid-12-monooxygenase; sterol 12 alpha hydroxylase; sterol 12 alpha-hydroxylase; sterol 12-alpha-hydroxylase; 12alpha hydroxylase; 12alpha-hydroxylase; 12 alpha-hydroxylase, sterol; 12-alpha-hydroxylase; 12 alpha hydroxylase; steroid 12 alpha hydroxylase;

MeSH CAS label : steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating);

Registry Number MeSH : EC 1.14.-; EC 1.14.18.8;

Is substance : O;

UNII : EC 1.14.18.8;

Details

Origin ID

D013253;

UMLS CUI

C0038315;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase [NCIt concept]
Record concept(s)
- steroid 12-alpha-Hydroxylase [MeSH concept]
Related MeSH Supplementary Concept(s)
- 7 alpha-hydroxy-4-cholesten-3-one-12 alpha monooxygenase [MeSH Supplementary Concept]
- 7-hydroxycholesterol-12-alpha-hydroxylase [MeSH Supplementary Concept]
- chenodeoxycholate hydroxylase [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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