cholesterol 7-alpha-hydroxylase

Preferred Label : cholesterol 7-alpha-hydroxylase;

MeSH definition : A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.;

MeSH synonym : cholesterol 7 hydroxylase; cytochrome p450 7; cyp7; cytochrome p-450 cyp7; cytochrome p 450 cyp7; cholesterol 7-alpha-monooxygenase; cyp 7; cholesterol 7alpha-hydroxylase; cholesterol-7-hydroxylase; cholesterol 7 alpha monooxygenase; cholesterol 7alpha hydroxylase; cyp 7a; cyp7a; cholesterol 7 alpha hydroxylase;

MeSH CAS label : Cholesterol,NADPH:oxygen oxidoreductase (7 alpha-hydroxylating);

MeSH Related Number : 9037-53-0 (CAS RN);

Registry Number MeSH : EC 1.14.13.17; EC 1.14.14.23;

Is substance : O;

UNII : EC 1.14.14.23;

Details

Origin ID

D002790;

UMLS CUI

C0008396;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Cholesterol 7-Alpha-Monooxygenase [NCIt concept]
Indexing information
- 7-ketocholesterol [MeSH Supplementary Concept]
Record concept(s)
- cholesterol 7-alpha-Hydroxylase [MeSH concept]
Related MeSH Supplementary Concept(s)
- CYP-33E2 protein, C elegans [MeSH Supplementary Concept]
- CYP7A1 protein, human [MeSH Supplementary Concept]
- CYP7A1 protein, rat [MeSH Supplementary Concept]
- Cyp7a1 protein, mouse [MeSH Supplementary Concept]
- Cyp7a1 protein, zebrafish [MeSH Supplementary Concept]
- deoxycholate 7-alpha-hydroxylase [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cholesterol 7alpha-monooxygenase (substance) [SNOMED CT concept]
- cholesterol 7alpha-monooxygenase [SNOMED Notion]

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