NCIt synonyms : HAKRD; DD/BABP; MCDR2; HBAB; BABP; DD; DDH2; DD2; Aldo-Keto Reductase Family 1, Member C2 wt Allele; DD-2; SRXY8; Aldo-Keto Reductase Family 1, Member C2 (Dihydrodiol Dehydrogenase 2; Bile Acid Binding
Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III) Gene;
NCIt definition : Human AKR1C2 wild-type allele is located within 10p15-p14 and is approximately 30
kb in length. This allele, which encodes aldo-keto reductase family 1 member C2 protein,
is involved in the metabolism of steroid hormones and the inactivation of androgens.
Mutations in this gene are associated with 46XY sex reversal 8.;
NCIt note : Three transcript variants encoding two different isoforms have been found for this
gene.;