11-Beta-Hydroxysteroid Dehydrogenase 1

Preferred Label : 11-Beta-Hydroxysteroid Dehydrogenase 1;

NCIt synonyms : 11-DH; EC 1.1.1.146; 7-Oxosteroid Reductase; 11-Beta-Hydroxysteroid Dehydrogenase, Type I; 11-Beta-HSD1; HSD11B1; Short Chain Dehydrogenase/Reductase Family 26C Member 1; Corticosteroid 11-Beta-Dehydrogenase Isozyme 1; EC 1.1.1.201;

NCIt definition : 11-beta-hydroxysteroid dehydrogenase 1 (292 aa, 32 kDa) is encoded by the human HSD11B1 gene. This protein is involved in cortisone metabolism.;

NCIt note : A gain of function mutation that changes the amino acid asparagine at position 367 to threonine is associated with castration-resistant prostate cancer. (Cell. 2013; 154:1074-1084.);

PubMed : 23993097;

Details

Origin ID

C113167;

UMLS CUI

C3715112;

Automatic exact mappings (from CISMeF team)
- 11-beta-hydroxysteroid dehydrogenase type 1 [MeSH Descriptor]
- 11-beta-hydroxysteroid dehydrogenase, type I [OMIM gene]
OMIM relation
- 11-beta-hydroxysteroid dehydrogenase, type I [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HSD11B1 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Metabolic Syndrome Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]
is_target
- HSD-1 Inhibitor SPI-62 [NCIt concept]

Keyword's position in hierarchy(ies) :

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