Preferred Label : Clofutriben;
NCIt synonyms : 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor SPI-62;
NCIt definition : An orally bioavailable selective inhibitor of the enzyme 11beta-hydroxysteroid dehydrogenase
type 1 (11b-HSD1; 11bHSD1; HSD11B1; HSD1; HSD-1), with potential protective activity
for disorders of corticosteroid excess. Upon oral administration, clofutriben selectively
binds to and inhibits the activity of HSD-1. This prevents the conversion of cortisone
to the active hormone cortisol and thereby preventing the activation of the glucocorticoid
receptors (GRs). By blocking cortisol production in metabolic tissues, clofutriben
may inhibit the adverse metabolic effects that are caused by exogenous administration
of glucocorticoids or in disorders in which cortisol is secreted in excess. HSD-1
is highly expressed in metabolic tissues, such as liver, skeletal muscle, and adipose
tissue. It plays a crucial role in regulating the production of cortisol to activate
the GRs.;
UNII : 4L1TY1U5VC;
CAS number : 1204178-50-6;
Molecule name : AS2473662; ASP 3662; ASP-3662; SPI 62; HDD-1697; SPI-62;
NCI Metathesaurus CUI : CL1921951;
Origin ID : C203214;
UMLS CUI : C5909090;
Semantic type(s)
- concept_is_in_subset
- has_target
