UDP-Glucuronosyltransferase 2B15

Preferred Label : UDP-Glucuronosyltransferase 2B15;

NCIt synonyms : UDP-Glucuronosyltransferase UGT2B15; UDPGT 2B15; UDPGTh-3; UDP-Glucuronyltransferase, Family 2, Beta-15; UDP-Glucuronosyltransferase 2B8; UDP Glycosyltransferase 2 Family, Polypeptide B15; UDP Glycosyltransferase 2 Family, Member B15; EC 2.4.1.17; UDP Glycosyltransferase 2B15; HLUG4; UDPGT 2B8; UGT2B15;

NCIt definition : UDP-glucuronosyltransferase 2B15 (530 aa, 61 kDa) is encoded by the human UGT2B15 gene. This protein is involved in the catabolism of xenobiotics and steroids.;

NCIt note : Substrates for UDP-glucoronosyltransferase 2B15 include several classes of xenobiotic substrates, such as simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. (UniProt);

Details

Origin ID

C105422;

UMLS CUI

C3537396;

OMIM relation
- Uridine diphosphate glycosyltransferase 2 family, member b15 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Glycosyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- UGT2B15 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ascorbate and Aldarate Metabolism Pathway [NCIt concept]
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Pentose and Glucuronate Interconversions Pathway [NCIt concept]
- Porphyrin and Chlorophyll Metabolism Pathway [NCIt concept]
- Retinol Metabolism Pathway [NCIt concept]
- Starch and Sucrose Metabolism Pathway [NCIt concept]
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Glycosylation [NCIt concept]
- Steroid Metabolic Process [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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