Aldo-Keto Reductase Family 1 Member C3

Preferred Label : Aldo-Keto Reductase Family 1 Member C3;

NCIt synonyms : 3-Alpha-HSD Type II, Brain; EC 1.-.-.-; DD3; Dihydrodiol Dehydrogenase X; 17-Beta-HSD 5; Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase; Indanol Dehydrogenase; 17-Beta-Hydroxysteroid Dehydrogenase Type 5; HA1753; Dihydrodiol Dehydrogenase Type I; PGFS; 3-Alpha-Hydroxysteroid Dehydrogenase Type 2; Chlordecone Reductase Homolog HAKRb; Hydroxysteroid (17-Beta) Dehydrogenase 5; Aldo-Keto Reductase B; Testosterone 17-Beta-Dehydrogenase 5; Dihydrodiol Dehydrogenase 3; 3-Alpha Hydroxysteroid Dehydrogenase, Type II; 3-Alpha-HSD Type 2; Type IIb 3-Alpha Hydroxysteroid Dehydrogenase; DD-3; 17-Beta-Hydroxysteroid Dehydrogenase V; Aldo-Keto Reductase 1C3; AKR1C3;

NCIt definition : Aldo-keto reductase family 1 member C3 (323 aa, 37 kDa) is encoded by the human AKR1C3 gene. This protein is involved in steroid and prostaglandin metabolism.;

NCIt note : Aldo-keto reductase family 1 member C3 is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) and selective seratonin reuptake inhibitors (SSRIs). (UniProt); Aldo-keto reductase family 1 member C3 has multiple enzymatic activites including those in EC 1.1.1.357, EC 1.1.1.112; EC 1.1.1.188, EC 1.1.1.239, EC 1.1.1.64, and EC 1.3.1.20. (UniProt);

Details

Origin ID

C129054;

UMLS CUI

C1453067;

Automatic exact mappings (from CISMeF team)
- Aldo-Keto Reductase Family 1 Member C3 [MeSH Descriptor]
- Aldo-Keto Reductase Family 1 Member C3 [MeSH concept]
- Aldo-keto reductase family 1, member 1 [OMIM gene]
- Aldo-keto reductase family 1, member c3 [OMIM gene]
- Endothelin-converting enzyme 1 (substance) [SNOMED CT concept]
- Indanol dehydrogenase (substance) [SNOMED CT concept]
- Prostate cancer antigen 3 [OMIM gene]
- aldo-keto reductase family 1 member A1 [HGNC gene]
- aldo-keto reductase family 1 member C3 [HGNC gene]
- indanol dehydrogenase [MeSH concept]
- indanol dehydrogenase [MeSH Supplementary Concept]
- indanol dehydrogenase [SNOMED Notion]
- trans-1,2-Dihydrobenzene-1,2-diol dehydrogenase (substance) [SNOMED CT concept]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [MeSH Supplementary Concept]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [MeSH concept]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [SNOMED Notion]
OMIM relation
- Aldo-keto reductase family 1, member c3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- AKR1C3 protein, human [MeSH Supplementary Concept]
- AKR1C3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AKR1C3 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arachidonic Acid Metabolism Pathway [NCIt concept]
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Eicosanoid Modulation [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]
is_target
- AKR1C3-activated Prodrug AST-3424 [NCIt concept]

Keyword's position in hierarchy(ies) :

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