Estradiol 17-Beta-Dehydrogenase 1

Preferred Label : Estradiol 17-Beta-Dehydrogenase 1;

NCIt synonyms : Hydroxysteroid (17-Beta) Dehydrogenase 1 Isoform; E2DH; 20-alpha-HSD; 17-Beta-HSD 1; 17-Beta-Hydroxysteroid Dehydrogenase I; 17-Beta-HSD I; 17-Beta-Hydroxysteroid Dehydrogenase Type 1; Placental 17-Beta-Hydroxysteroid Dehydrogenase; 20 Alpha-Hydroxysteroid Dehydrogenase; Estradiol 17-Beta-Dehydrogenase-1; Short Chain Dehydrogenase/Reductase Family 28CE, Member 1; HSD17B1;

NCIt definition : Estradiol 17-beta-dehydrogenase 1 (328 aa, 35 kDa) is encoded by the human HSD17B1 gene. This protein is involved in the conversion of both estrogens and androgens to their active intracellular forms.;

Details

Origin ID

C104037;

UMLS CUI

C1738873;

Automatic exact mappings (from CISMeF team)
- 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity [GO term]
- 17-beta-hydroxysteroid dehydrogenase I [OMIM gene]
- 20-alpha-Hydroxysteroid dehydrogenase [MeSH concept]
- 20-alpha-hydroxysteroid dehydrogenase [MeSH Descriptor]
- 20-alpha-hydroxysteroid dehydrogenase (substance) [SNOMED CT concept]
- hydroxysteroid 17-beta dehydrogenase 1 [HGNC gene]
OMIM relation
- 17-beta-hydroxysteroid dehydrogenase I [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HSD17B1 protein, human [MeSH concept]
- HSD17B1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HSD17B1 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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