Cholesterol Side-Chain Cleavage Enzyme, Mitochondrial

Preferred Label : Cholesterol Side-Chain Cleavage Enzyme, Mitochondrial;

NCIt synonyms : Steroid 20-22-Lyase; Mitochondrial Cytochrome P450 11A1; Cholesterol 20-22 Desmolase; Cytochrome P450 Subfamily XIA (Cholesterol Side Chain Cleavage); Cholesterol Monooxygenase (Side-Chain Cleaving); Cytochrome P450 Subfamily XIA; Cholesterol Side-Chain Cleavage Enzyme; CYPXIA1; CYP11A1; Cytochrome P-450scc; Cholesterol Desmolase; P450(scc); Cytochrome P450C11A1; Cytochrome P450(scc); Cytochrome P450 11A1; EC 1.14.15.6; Cytochrome-P450C11A1;

NCIt definition : Cholesterol side-chain cleavage enzyme, mitochondrial (521 aa, 60 kDa) is encoded by the human CYP11A1 gene. This protein plays a role in the catalysis of the side-chain cleavage reaction converting cholesterol to pregnenolone.;

Details

Origin ID

C40057;

UMLS CUI

C5441693;

Currated CISMeF NLP mapping
- Cholesterol monooxygenase (side-chain cleaving) (substance) [SNOMED CT concept]
- cholesterol Side-Chain cleavage enzyme [MeSH concept]
- cholesterol monooxygenase (side-chain cleaving) [SNOMED Notion]
- cholesterol side-chain cleavage enzyme [MeSH Descriptor]
OMIM relation
- Cytochrome p450, subfamily xia, polypeptide 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cholesterol monooxygenase (side-chain cleaving) (substance) [SNOMED CT concept]
- cholesterol Side-Chain cleavage enzyme [MeSH concept]
- cholesterol monooxygenase (side-chain cleaving) [SNOMED Notion]
- cholesterol side-chain cleavage enzyme [MeSH Descriptor]
gene_encodes_gene_product
- CYP11A1 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]
is_target
- Opevesostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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