cholesterol side-chain cleavage enzyme

Preferred Label : cholesterol side-chain cleavage enzyme;

MeSH definition : A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.;

MeSH synonym : cholesterol monooxygenase (side-chain-cleaving); cytochrome p450 11a1; cyp11a1; cytochrome p-450 cyp11a1; cytochrome p-450(scc); cholesterol desmolase; cyp 11a1; cytochrome p 450 cyp11a1; cytochrome p450scc; 20,22 desmolase; 20,22-desmolase; cholesterol side chain cleavage enzyme;

MeSH CAS label : cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving);

Registry Number MeSH : EC 1.14.15.6;

Wikipedia link : https://en.wikipedia.org/wiki/Cholesterol side-chain cleavage enzyme;

Is substance : O;

UNII : EC 1.14.15.6;

Details

Origin ID

D002786;

UMLS CUI

C0008381;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Cholesterol Side-Chain Cleavage Enzyme, Mitochondrial [NCIt concept]
- Cholesterol monooxygenase (side-chain cleaving) (substance) [SNOMED CT concept]
- cholesterol monooxygenase (side-chain cleaving) [SNOMED Notion]
Indexing information
- 20-(1,5-hexadiynyl)-5-pregnen-3,20-diol [MeSH Supplementary Concept]
- 20-(1-hexynyl)-5-pregnen-3,20-diol [MeSH Supplementary Concept]
- 20-(1-propynyl)-5-pregnen-3,20-diol [MeSH Supplementary Concept]
- 22-thio-23,24-bisnor-5-cholen-3-ol [MeSH Supplementary Concept]
Record concept(s)
- cholesterol Side-Chain cleavage enzyme [MeSH concept]
Related MeSH Supplementary Concept(s)
- cyp11a2 protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cholesterol Side-Chain Cleavage Enzyme, Mitochondrial [NCIt concept]
- Cholesterol monooxygenase (side-chain cleaving) (substance) [SNOMED CT concept]
- cholesterol monooxygenase (side-chain cleaving) [SNOMED Notion]

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