Preferred Label : Opevesostat;
NCIt synonyms : CYP11A1 inhibitor ODM-208;
NCIt definition : An orally bioavailable, non-steroidal, selective inhibitor of the enzyme cytochrome
450 side-chain cleavage (scc) (CYP11A1), with potential antineoplastic activity. Upon
oral administration, opevesostat targets, binds to and inhibits the activity of CYP11A1.
This prevents the synthesis of all steroid hormones and their precursors. This may
inhibit proliferation of hormone-positive tumor cells. CYP11A1, a mitochondrial enzyme,
catalyzes the conversion of cholesterol to pregnenolone (Preg), which is the first
rate-liming step in steroid hormone biosynthesis.;
UNII : 1Z7MAV4KQC;
CAS number : 2231294-96-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2231294-96-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : ODM-208; ODM 208; MK-5684; MK 5684;
NCI Metathesaurus CUI : CL935891;
Origin ID : C156744;
UMLS CUI : C4745035;
Semantic type(s)
- concept_is_in_subset
- has_target
