Preferred Label : CYP11A1 Inhibitor ACE-232;
NCIt definition : An orally bioavailable inhibitor of the enzyme cytochrome 450 side-chain cleavage
(scc) (CYP11A1; P450 11A1), with potential antineoplastic activity. Upon oral administration,
CYP11A1 inhibitor ACE-232 selectively targets, binds to and inhibits the activity
of CYP11A1. This prevents the synthesis of all steroid hormones and their precursors.
This may inhibit the proliferation of hormone-positive tumor cells. CYP11A1, a mitochondrial
enzyme, catalyzes the conversion of cholesterol to pregnenolone, which is the first
rate-limiting step in steroid hormone biosynthesis.;
Molecule name : ACE 232; ACE-232;
Origin ID : C215027;
concept_is_in_subset
- has_target
