NCIt definition : Human CYP1A1 wild-type allele is located within 15q22-q24 and is approximately 6 kb
in length. This allele, which encodes cytochrome P450 1A1 protein, plays a role in
the metabolism of polyaromatic hydrocarbons (PAHs). Individuals with a high-inducibility
phenotype, who exhibit elevated CYP1A1 gene expression in response to PAHs, may be
at greater risk for cigarette smoke-induced bronchogenic carcinoma.;