Very-Long-Chain 3-Oxoacyl-CoA Reductase

Preferred Label : Very-Long-Chain 3-Oxoacyl-CoA Reductase;

NCIt synonyms : Hydroxysteroid 17-Beta Dehydrogenase 12; 17-Beta-Hydroxysteroid Dehydrogenase 12; Estradiol 17-Beta-Dehydrogenase 12; EC 1.1.1.62; EC 1.1.1.330; KAR; 17-Beta-HSD 12; Short Chain Dehydrogenase/Reductase Family 12C Member 1; HSD17B12; 3-Ketoacyl-CoA Reductase;

NCIt definition : Very-long-chain 3-oxoacyl-CoA reductase (312 aa, 34 kDa) is encoded by the human HSD17B12 gene. This protein is involved in fatty acid elongation and estrogen synthesis.;

Details

Origin ID

C184998;

UMLS CUI

C1721338;

Automatic exact mappings (from CISMeF team)
- 17-beta-hydroxysteroid dehydrogenase XII [OMIM gene]
- Malate dehydrogenase, soluble [OMIM gene]
- diiodophenylpyruvate reductase activity [GO term]
- hydroxysteroid 17-beta dehydrogenase 12 [HGNC gene]
OMIM relation
- 17-beta-hydroxysteroid dehydrogenase XII [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- type 12 17beta-hydroxysteroid dehydrogenase, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HSD17B12 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Fatty Acid Elongation Pathway in Mitochondria [NCIt concept]
- Fatty Acid Metabolism Pathway [NCIt concept]
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Estrogen Metabolic Process [NCIt concept]
- Fatty Acid Metabolism [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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