Preferred Label : Iodine I 125 RISAD-P;
NCIt synonyms : 125IRISAD-P; 5-[125I]iodo-3'-O-(17b-succinyl-5a-androstan-3-one)-2'-deoxyuridin-5'-yl Monophosphate; [125]I-RISAD-P; (125) IRISAD-P; I 125 RISAD-P; [125]I-5-Radioiodo-3'-O-(17beta-succinyl-5alpha-androstan-3-one)-2'-deoxyuridin-5'-yl
Phosphate;
NCIt definition : A radioconjugate containing an androgen receptor (AR) targeting agent, 5-radioiodo-3'-O-(17beta-succinyl-5alpha-androstan-3-one)-2'-deoxyuridin-5'-yl
phosphate (RISAD-P), labeled with the radioisotope iodine I 125 ([125]I-RISAD-P),
with potential use as an imaging agent for single photon emission computed tomography
(SPECT) imaging. Upon administration, iodine I 125 RISAD-P selectively binds to and
is taken up by AR. Upon SPECT imaging, AR-expressing tumor cells can be imaged and
AR expression levels can be assessed. AR, which is overexpressed on certain tumor
cells, plays key roles in tumor cell growth and survival.;
NCI Metathesaurus CUI : CL508856;
Origin ID : C127815;
UMLS CUI : C4287592;
Semantic type(s)
- concept_is_in_subset
- has_target
