Darolutamide - CISMeF

Preferred Label : Darolutamide;

NCIt synonyms : Antiandrogen ODM-201;

NCIt definition : A formulation containing an androgen receptor (AR) antagonist with potential antineoplastic activity. Darolutamide binds to ARs in target tissues; subsequently, inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes that regulate prostate cancer cell proliferation. This ultimately leads to an inhibition of growth in AR-expressing prostate cancer cells.;

UNII : X05U0N2RCO;

InChIKey : BLIJXOOIHRSQRB-PXYINDEMSA-N;

CAS number : 1297538-32-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1297538-32-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Nubeqa;

Molecule name : ODM-201; BAY 1841788; BAY-1841788; ODM 201;

Codes from synonyms : 141;

Details

Origin ID

C104748;

UMLS CUI

C4547776;

Automatic exact mappings (from CISMeF team)
- Darolutamide [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Darolutamide (substance) [SNOMED CT concept]
- darolutamide [MeSH concept]
- darolutamide [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Nubeqa [MeSH concept]
- Product containing darolutamide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Darolutamide (substance) [SNOMED CT concept]
- Product containing darolutamide (medicinal product) [SNOMED CT concept]
- darolutamide [MeSH Supplementary Concept]
- darolutamide [ATC Code]
Validated automatic mappings to BTNT
- darolutamide [ATC Code]
chemical_or_drug_affects_gene_product
- Androgen Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Negative Regulation of Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- Operational Ontology for Radiation Oncology Prostate Cancer Terminology [NCIt concept]
has_target
- Androgen Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Darolutamide Regimen [NCIt concept]
- Darolutamide/Docetaxel Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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