Preferred Label : Ralaniten Acetate;
NCIt synonyms : AR Inhibitor EPI-506; 1,2-Propanediol, 3-(4-(1-(4-((2S)-2-(acetyloxy)-3-chloropropoxy)phenyl)-1-methylethyl)phenoxy)-,
1,2-Diacetate, (2S)-;
NCIt definition : An orally bioavailable, small molecule inhibitor of the acetate form of ralaniten,
a N-terminal domain (NTD) of the androgen receptor (AR), with potential antineoplastic
activity. Upon oral administration of ralaniten acetate, ralaniten specifically binds
to the NTD of AR, thereby inhibiting both AR activation and the AR-mediated signaling
pathway. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed
in prostate cancers and is involved in proliferation, survival and chemoresistance
of tumor cells.;
UNII : L10K286T2H;
InChIKey : HGHVYYKTOXUQNT-CLJLJLNGSA-N;
CAS number : 1637573-04-6;
Molecule name : EPI-506;
NCI Metathesaurus CUI : CL502886;
Origin ID : C124654;
UMLS CUI : C4682411;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
