Preferred Label : Testosterone Gel;
NCIt definition : A topical gel preparation of synthetic testosterone. In vivo, testosterone is irreversibly
converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase.
Testosterone or DHT ligand-androgen receptor complexes act as transcription factor
complexes, stimulating the expression of various responsive genes, resulting in an
increase in protein anabolism, a decrease in amino acid catabolism, and retention
of nitrogen, potassium, and phosphorus; DHT binds with higher affinity to nuclear
androgen receptors than testosterone. In addition, testosterone is irreversibly converted
to estradiol by the enzyme complex aromatase, particularly in the liver and adipose
tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics
related to the internal and external genitalia, skeletal muscle, and hair follicles;
estradiol promotes epiphyseal maturation and bone mineralization.;
Drug name : AndroGel; Fortesta;
Origin ID : C74081;
UMLS CUI : C2348756;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
