NCIt definition : A nasal gel containing the human androgen testosterone that is used as a replacement
agent for low or missing endogenous testosterone caused by various conditions. Upon
intranasal administration of testosterone nasal gel using a pump, testosterone is
taken up systemically and is irreversibly converted to dihydrotestosterone (DHT) in
target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen
receptor complexes act as transcription factor complexes, stimulating the expression
of various responsive genes. Testosterone and DHT promote the growth, development
and maintenance of male sex organs and the maintenance of secondary sex characteristics.
In addition, testosterone is irreversibly converted to estradiol by the enzyme complex
aromatase, particularly in the liver and adipose tissue.;
Semantic type(s)