AR Antagonist BMS-641988

Preferred Label : AR Antagonist BMS-641988;

NCIt related terms : BMS-641988;

NCIt definition : An androgen receptor (AR) antagonist with potential antineoplastic and anti-androgenic activities. BMS-641988 binds to the androgen receptor in target tissues, thereby preventing androgen-induced receptor activation, and facilitates the formation of inactive complexes that cannot be translocated to the nucleus. This may inhibit androgen-dependent gene expression, subsequently leading to an inhibition of cell growth and apoptosis in AR-expressing cells.;

UNII : W17M53Y8IM;

CAS number : 1093276-09-5;

Molecule name : BMS-641988;

Détails

Origin ID

C62522;

UMLS CUI

C1831892;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BMS 641988 [MeSH concept]
- BMS 641988 [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Androgen Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Negative Regulation of Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Androgen Receptor [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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