NCIt definition : A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone
is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme
5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription
factor complexes, stimulating the expression of various responsive genes. DHT binds
with higher affinity to androgen receptors than testosterone, activating gene expression
more efficiently. In addition, testosterone is irreversibly converted to estradiol
by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone
and DHT promote the development and maintenance of male sex characteristics related
to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol
promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by
the liver, therapeutic testosterone is generally administered as an ester derivative.;
UNII : 3XMK78S47O;
InChIKey : MUMGGOZAMZWBJJ-DYKIIFRCSA-N;
CAS number : 58-22-0;
Drug name : Mertestate; Testolin; Testostroval-PA; Testro AQ; Testostroval; Virosterone; Testoderm;
Chemical formula : C19H28O2;
NCI Metathesaurus CUI : CL1379971;
NSC code : 9700;
ChEBI ID : CHEBI:17347;
Codes from synonyms : NSC0017591; 00437; NSC0009700;