Preferred Label : Rezvilutamide;
NCIt synonyms : Androgen Receptor Antagonist SHR3680;
NCIt definition : An orally bioavailable androgen receptor (AR) antagonist with potential antineoplastic
activity. Upon administration, rezvilutamide competitively binds to AR in target tissues,
which both prevents androgen-induced receptor activation and facilitates the formation
of inactive complexes that cannot be translocated to the nucleus. This prevents binding
to and transcription of AR-responsive genes, inhibits the expression of genes that
regulate prostate cancer cell proliferation, and may lead to an inhibition of cell
growth of AR-expressing tumor cells. ARs are overexpressed in prostate cancer and
play a key role in prostate cancer cell proliferation.;
UNII : 70FJN2AW22;
InChIKey : KRBMOYIWQCZVHA-INIZCTEOSA-N;
CAS number : 1572045-62-5;
Molecule name : SHR-3680; SHR 3680;
NCI Metathesaurus CUI : CL1413047;
Codes from synonyms : 33912;
Origin ID : C175852;
UMLS CUI : C5446792;
Semantic type(s)
- concept_is_in_subset
- has_target
