Preferred Label : Cyproterone Acetate;
NCIt synonyms : Chloro-6-hydroxy-17 Alpha Methylene-1 Alpha, 2 Alpha Pregnadiene-4,6 Dione-3, 20 Acetate; 6-Chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
Acetate; Cyproteronazetat; Cyproteroni Acetas; 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(Acetyloxy)-6-chloro-1,2-dihydro-,
(1beta,2beta)-; CyPat;
NCIt related terms : Androcur; SH 714; SH-714;
NCIt definition : The acetate salt of a synthetic steroidal antiandrogen with weak progestational and
antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing
androgen-induced receptor activation in target tissues and inhibiting the growth of
testosterone-sensitive tumor cells. This agent also exerts progestational agonist
properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting
in reductions in testicular androgen secretion and serum testosterone levels. Treatment
with cyproterone alone results in incomplete suppression of serum testosterone levels.;
Alternative definition : NCI-GLOSS: A synthetic hormone being studied for treatment of hot flashes in men with
prostate cancer who have had both testicles removed by surgery.;
UNII : 4KM2BN5JHF;
InChIKey : UWFYSQMTEOIJJG-FDTZYFLXSA-N;
CAS number : 427-51-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 427-51-0
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G-SRS /a ;
Drug name : Dianette; Cyprostat; Cyprone; Andro-Diane; Diane; Androcur;
Molecule name : SH-714;
Chemical formula : C24H29ClO4;
NSC code : 81430;
ChEBI ID : CHEBI:50743;
Codes from synonyms : 00422; NSC0081430; CDR0000046077; 125;
Origin ID : C1059;
UMLS CUI : C0056855;
Automatic exact mappings (from CISMeF team)
- Cypate [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
