NCIt definition : A small molecule and androgen receptor (AR) antagonist with potential antineoplastic
activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced
receptor activation and facilitating the formation of inactive complexes that cannot
be translocated to the nucleus. This prevents binding to and transcription of AR-responsive
genes. This ultimately inhibits the expression of genes that regulate prostate cancer
cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor
cells.;
UNII : 4T36H88UA7;
InChIKey : HJBWBFZLDZWPHF-UHFFFAOYSA-N;
CAS number : 956104-40-8;
Drug name : Erleada;
Molecule name : ARN-509; ARN 509; JNJ-56021927; JNJ 56021927;