Apalutamide - CISMeF

Preferred Label : Apalutamide;

NCIt synonyms : 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro(3.4)octan-5-yl)-2-fluoro-N-methylbenzamide;

NCIt definition : A small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.;

UNII : 4T36H88UA7;

InChIKey : HJBWBFZLDZWPHF-UHFFFAOYSA-N;

CAS number : 956104-40-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 956104-40-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Erleada;

Molecule name : ARN-509; ARN 509; JNJ-56021927; JNJ 56021927;

Codes from synonyms : 39;

Details

Origin ID

C92574;

UMLS CUI

C4329353;

Automatic exact mappings (from CISMeF team)
- Apalutamide [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Apalutamide (substance) [SNOMED CT concept]
- apalutamide [MeSH Supplementary Concept]
- apalutamide [MeSH concept]
See also inter- (CISMeF)
- Erleada [MeSH concept]
- Product containing apalutamide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Apalutamide (substance) [SNOMED CT concept]
- Product containing apalutamide (medicinal product) [SNOMED CT concept]
- apalutamide [MeSH Supplementary Concept]
- apalutamide [ATC Code]
Validated automatic mappings to BTNT
- apalutamide [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- Operational Ontology for Radiation Oncology Prostate Cancer Terminology [NCIt concept]
has_target
- Androgen Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Apalutamide Regimen [NCIt concept]
- Apalutamide/Degarelix Regimen [NCIt concept]
- Apalutamide/Goserelin Regimen [NCIt concept]
- Apalutamide/Leuprolide Regimen [NCIt concept]
- Apalutamide/Triptorelin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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