Preferred Label : Oral Microencapsulated Diindolylmethane;
NCIt synonyms : BR-DIM;
NCIt definition : An orally bioavailable microencapsulated formulation of diindolylmethane, an indole
phytonutrient found in cruciferous vegetables, with estrogen-modulating, antiandrogenic,
and potential antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane
(DIM) modulates estrogen balance by reducing the levels of 16-hydroxy estrogen metabolites
and increasing the formation of beneficial 2-hydroxy estrogen metabolites. DIM also
antagonizes androgen receptor activity, which may result in diminished cell proliferation
and apoptosis in susceptible tumor cell populations. Pure DIM, which is relatively
hydrophobic, is poorly absorbed after oral administration. This oral formulation,
which consists of DIM, d-alpha-tocopheryl acid succinate, phosphatidylcholine, and
silica microencapsulated in starch, significantly improves the gastrointestinal absorption
of DIM.;
Drug name : BioResponse DIM;
NCI Metathesaurus CUI : CL377701;
Origin ID : C71132;
UMLS CUI : C2347401;
Semantic type(s)
- concept_is_in_subset
- has_target
