" /> Androgen Receptor Inhibitor ONCT-534 - CISMeF





Preferred Label : Androgen Receptor Inhibitor ONCT-534;

NCIt synonyms : AR Inhibitor ONCT-534; DAARI ONCT-534; Dual-action Androgen Receptor Inhibitor ONCT-534;

NCIt definition : An orally bioavailable dual-action androgen receptor (AR) inhibitor, with potential antineoplastic activity. Upon oral administration, AR inhibitor ONCT-534 targets and binds to both the ligand-binding domain (LBD) and the N-terminal domain (NTD) of the AR, and inhibits AR-mediated signaling and induces the degradation of AR and AR splice variant (AR-SV) proteins. This may inhibit cell growth in AR-overexpressing tumor cells, including those with AR amplification, mutations in the AR LBD, and AR-SVs with loss of the AR LBD. AR is overexpressed in prostate cancers and is involved in the proliferation, survival and chemoresistance of tumor cells.;

Molecule name : ONCT 534; ONCT-534;

NCI Metathesaurus CUI : CL1922098;

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04/05/2025


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