Oocyte Meiosis Pathway

Preferred Label : Oocyte Meiosis Pathway;

NCIt related terms : Oocyte meiosis;

Alternative definition : KEGG: During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2 , which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.;

KEGG ID : hsa04114;

Details

Origin ID

C91472;

UMLS CUI

C2984284;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 14-3-3 Protein Epsilon [NCIt concept]
- 14-3-3 Protein Theta [NCIt concept]
- Adenylate Cyclase Type 9 [NCIt concept]
- Androgen Receptor [NCIt concept]
- Aurora Kinase A [NCIt concept]
- Calcineurin Subunit B Type 1 [NCIt concept]
- Calcineurin Subunit B Type 2 [NCIt concept]
- Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha [NCIt concept]
- Calmodulin [NCIt concept]
- Cullin-1 [NCIt concept]
- Cytoplasmic Polyadenylation Element-Binding Protein 3 [NCIt concept]
- F-Box Only Protein 5 [NCIt concept]
- F-Box/WD Repeat-Containing Protein 1A [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 2 [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Membrane-Associated Tyrosine- and Threonine-Specific Cdc2-Inhibitory Kinase [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2A [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2B [NCIt concept]
- Progesterone Receptor [NCIt concept]
- Proto-Oncogene Serine/Threonine-Protein Kinase mos [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-1 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-2 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-3 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-6 [NCIt concept]
- S-Phase Kinase-Associated Protein 1 [NCIt concept]
- STE20-Like Serine/Threonine-Protein Kinase [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase PLK1 [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit [NCIt concept]
- Shugoshin 1 [NCIt concept]
- Structural Maintenance of Chromosomes Protein 3 [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ADCY9 wt Allele [NCIt concept]
- AR wt Allele [NCIt concept]
- AURKA wt Allele [NCIt concept]
- BTRC wt Allele [NCIt concept]
- BUB1 wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CAMK2A wt Allele [NCIt concept]
- CPEB3 wt Allele [NCIt concept]
- CUL1 wt Allele [NCIt concept]
- FBXO5 wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- ITPR1 wt Allele [NCIt concept]
- ITPR2 wt Allele [NCIt concept]
- MAD2L1 wt Allele [NCIt concept]
- MAD2L2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MOS wt Allele [NCIt concept]
- PGR wt Allele [NCIt concept]
- PKMYT1 wt Allele [NCIt concept]
- PLK1 wt Allele [NCIt concept]
- PPP1CA wt Allele [NCIt concept]
- PPP1CB wt Allele [NCIt concept]
- PPP2CA wt Allele [NCIt concept]
- PPP2CB wt Allele [NCIt concept]
- PPP2R1A wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PPP3R1 wt Allele [NCIt concept]
- PPP3R2 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- RPS6KA1 wt Allele [NCIt concept]
- RPS6KA2 wt Allele [NCIt concept]
- RPS6KA3 wt Allele [NCIt concept]
- RPS6KA6 wt Allele [NCIt concept]
- SGO1 wt Allele [NCIt concept]
- SKP1 wt Allele [NCIt concept]
- SLK wt Allele [NCIt concept]
- SMC3 wt Allele [NCIt concept]
- YWHAE wt Allele [NCIt concept]
- YWHAQ wt Allele [NCIt concept]

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