Serine/Threonine-Protein Kinase PLK1

Preferred Label : Serine/Threonine-Protein Kinase PLK1;

NCIt synonyms : PLK; Polo-Like Kinase; Serine/Threonine-Protein Kinase 13; PLK-1; Polo-Like Kinase 1; Serine/Threonine Kinase PLK1; EC 2.7.11.21; STPK13; Polo Like Kinase; Serine/Threonine Protein Kinase PLK1;

NCIt definition : Serine/threonine-protein kinase PLK1 (603 aa, 68 kDa) is encoded by the human PLK1 gene. This protein is involved in protein phosphorylation and the regulation of both cell cycle progression and cytokinesis.;

NCIt note : Serine/threonine-protein kinase PLK1 is localized to centrosomes, centromeres/kinetochores, and the spindle midzone, where it may regulate both the organization and the function of the mitotic apparatus.;

Details

Origin ID

C17911;

UMLS CUI

C0290178;

OMIM relation
- Polo-like kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PLK1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PLK1 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Polo-like Kinase 1 Inhibitor GSK461364 [NCIt concept]
- Polo-like Kinase 1 Inhibitor MK1496 [NCIt concept]
- Rigosertib Sodium [NCIt concept]
gene_product_has_associated_anatomy
- Spindle Pole Body [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Polo-Box Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- PLK1 Signaling Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokinesis [NCIt concept]
- Mitosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Lipid Encapsulated Anti-PLK1 siRNA TKM-PLK1 [NCIt concept]
- Onvansertib [NCIt concept]
- PLK1 Inhibitor [NCIt concept]
- PLK1 Inhibitor TAK-960 [NCIt concept]
- Plk1 Inhibitor BI 2536 [NCIt concept]
- Plogosertib [NCIt concept]
- TTK/PLK1 Inhibitor BAL0891 [NCIt concept]
- Volasertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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