Plk1 Inhibitor BI 2536

Preferred Label : Plk1 Inhibitor BI 2536;

NCIt related terms : BI-2536; BI 2536;

NCIt definition : A small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It prevents cells from dividing and may block the growth of some tumors. It is a type of mitotic inhibitor.;

UNII : 4LJG22T9C6;

CAS number : 755038-02-9;

Molecule name : BI-2536; BI 2536;

Codes from synonyms : CDR0000468773;

Details

Origin ID

C49091;

UMLS CUI

C1706888;

Currated CISMeF NLP mapping
- BI 2536 [MeSH concept]
- BI 2536 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BI 2536 [MeSH Supplementary Concept]
- BI 2536 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase PLK1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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