Preferred Label : TTK/PLK1 Inhibitor BAL0891;
NCIt synonyms : TTK/PLK-1 Inhibitor BAL0891; Mitotic Checkpoint Inhibitor BAL0891; MCI Inhibitor BAL0891; Threonine Tyrosine Kinase/Polo-like Kinase 1 Inhibitor BAL0891;
NCIt definition : An inhibitor of threonine tyrosine kinase (TTK; monopolar spindle 1 kinase; Mps1)
and polo-like kinase 1 (PLK1; PLK-1; STPK13), with potential mitotic checkpoint inhibiting
(MCI) and antineoplastic activities. Upon administration, TTK/PLK1 inhibitor BAL0891
selectively targets, binds to and inhibits TTK and PLK1. This disrupts and inactivates
the spindle assembly checkpoint (SAC), which results in chromosomal misalignment and
missegregation, mitotic checkpoint complex destabilization, and induces G2/M-phase
cell-cycle arrest, aberrant cell division and apoptosis in TTK- and PLK1-overexpressing
tumor cells. PLK1, a serine/threonine kinase that is crucial for the activation of
the mitotic SAC and regulation of mitosis, plays a key role in tumor cell proliferation,
transformation and invasion. PLK1 expression is upregulated in a variety of tumor
cell types and high expression is associated with increased aggressiveness and poor
prognosis. TTK, a tyrosine and serine/threonine kinase expressed in proliferating
normal tissues, is essential for proper SAC functioning, chromosome alignment and
segregation. Overexpressed in various human tumors, TTK plays a key role in uncontrolled
tumor cell growth.;
Molecule name : TTK-CS-101; BAL-0891; BAL 0891;
NCI Metathesaurus CUI : CL1906281;
Origin ID : C198842;
UMLS CUI : C5854377;
Semantic type(s)
- concept_is_in_subset
- has_target
