" /> Rigosertib Sodium - CISMeF





Preferred Label : Rigosertib Sodium;

NCIt synonyms : Polo-like kinase 1 Inhibitor ON 01910.Na; Polo-like kinase 1 Inhibitor ON 01910 Na;

NCIt related terms : ON 01910.Na;

NCIt definition : The sodium salt form of rigosertib, a synthetic benzyl styryl sulfone analogue and Ras mimetic, with potential antineoplastic activity. Upon administration, rigosertib targets and binds to Ras-binding domain (RBD) found in many Ras effector proteins, including Raf kinase and phosphatidylinositol 3-kinase (PI3K). This prevents Ras from binding to its targets and inhibits Ras-mediated signaling pathways, including Ras/Raf/Erk, Ras/CRAF/polo-like kinase1 (Plk1), and Ras/ PI3K/Akt signaling pathways. This induces cell cycle arrest and apoptosis and inhibits proliferation in a variety of susceptible tumor cells.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks certain proteins that are needed for cell growth and may kill cancer cells. ON 01910.Na is a type of protein kinase inhibitor and a type of benzyl styryl sulfone analog.;

UNII : 406FL5G00V;

InChIKey : VLQLUZFVFXYXQE-USRGLUTNSA-M;

CAS number : 592542-60-4;

Molecule name : ON 01910.Na;

Chemical formula : C21H24NO8S.Na;

Codes from synonyms : CDR0000600479;

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05/07/2025


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