Preferred Label : Rigosertib;
NCIt synonyms : Glycine, N-(2-methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl) methyl)phenyl)-; N-(2-Methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl) phenyl)glycine;
NCIt definition : A synthetic benzyl styryl sulfone analogue and Ras mimetic, with potential antineoplastic
activity. Upon administration, rigosertib targets and binds to Ras-binding domain
(RBD) found in many Ras effector proteins, including Raf kinase and phosphatidylinositol
3-kinase (PI3K). This prevents Ras from binding to its targets and inhibits Ras-mediated
signaling pathways, including Ras/Raf/Erk, Ras/CRAF/polo-like kinase1 (Plk1), and
Ras/ PI3K/Akt signaling pathways. This induces cell cycle arrest and apoptosis and
inhibits proliferation in a variety of susceptible tumor cells.;
UNII : 67DOW7F9GL;
InChIKey : OWBFCJROIKNMGD-BQYQJAHWSA-N;
CAS number : 592542-59-1;
Molecule name : ON 01910;
NCI Metathesaurus CUI : CL553420;
Origin ID : C152216;
UMLS CUI : C3467794;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
