Aurora Kinase A

Preferred Label : Aurora Kinase A;

NCIt synonyms : Aurora-Related Kinase 1; Aurora Kinase A Protein; Aurora/IPL1-Related Kinase 1; hARK1; STK15; Serine/Threonine Kinase 6; Aurora/IPL1-Like Kinase; Serine/Threonine Kinase 15; Aurora A; STK6; Serine/Threonine Protein Kinase 15; IPL1-Related Kinase; Aurora A Kinase; Breast-Tumor-Amplified Kinase; Aurora-A; Aurora 2; Breast Tumor-Amplified Kinase; ARK-1; Serine/Threonine-Protein Kinase 15; Serine/Threonine-Protein Kinase Aurora-A; Serine/Threonine-Protein Kinase 6; Serine-Threonine Kinase-6; Protein Phosphatase 1, Regulatory Subunit 47;

NCIt definition : Aurora kinase A (403 aa, 46 kDa) is encoded by the human AURKA gene. This protein is involved in mediating microtubular structure and facilitating chromosome segregation during mitosis and meiosis.;

Details

Origin ID

C30006;

UMLS CUI

C3711557;

Automatic exact mappings (from CISMeF team)
- Aurora kinase a [OMIM gene]
Currated CISMeF NLP mapping
- aurora kinase A [MeSH Descriptor]
- aurora kinase A [MeSH concept]
False automatic mappings
- beta-adrenergic receptor kinase activity [GO term]
- myosin heavy chain kinase activity [GO term]
OMIM relation
- Aurora kinase a [OMIM gene]
See also inter- (CISMeF)
- Aurora kinase a [OMIM gene]
- aurora kinase A [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- AURKA protein, human [MeSH concept]
- AURKA protein, human [MeSH Supplementary Concept]
- aurora kinase A [MeSH concept]
- aurora kinase A [MeSH Descriptor]
Validated automatic mappings to BTNT
- AURKA protein, human [MeSH concept]
- AURKA protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- aurora kinases [MeSH concept]
- aurora kinases [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AURKA Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Alisertib [NCIt concept]
- Alisertib Sodium [NCIt concept]
- Aurora A Kinase Inhibitor JAB-2485 [NCIt concept]
- Aurora A Kinase Inhibitor LY3295668 [NCIt concept]
- Aurora A Kinase Inhibitor LY3295668 Erbumine [NCIt concept]
- Aurora A Kinase Inhibitor MK5108 [NCIt concept]
- Aurora A Kinase Inhibitor VIC-1911 [NCIt concept]
- Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076 [NCIt concept]
- Aurora B Serine/Threonine Kinase Inhibitor TAK-901 [NCIt concept]
- Aurora B/C Kinase Inhibitor GSK1070916A [NCIt concept]
- Aurora B/VEGFR/FGFR Inhibitor AL8326 [NCIt concept]
- Aurora Kinase A Inhibitor [NCIt concept]
- Aurora Kinase Inhibitor [NCIt concept]
- Aurora Kinase Inhibitor AMG 900 [NCIt concept]
- Aurora Kinase Inhibitor BI 811283 [NCIt concept]
- Aurora Kinase Inhibitor MLN8054 [NCIt concept]
- Aurora Kinase Inhibitor PF-03814735 [NCIt concept]
- Aurora Kinase Inhibitor SNS-314 [NCIt concept]
- Aurora Kinase Inhibitor TTP607 [NCIt concept]
- Aurora Kinase/VEGFR2 Inhibitor CYC116 [NCIt concept]
- BMX Inhibitor [NCIt concept]
- Barasertib [NCIt concept]
- Cenisertib [NCIt concept]
- Danusertib [NCIt concept]
- Defosbarasertib [NCIt concept]
- FLT3/ABL/Aurora Kinase Inhibitor KW-2449 [NCIt concept]
- Ibrutinib [NCIt concept]
- MEK/Aurora Kinase Inhibitor BI 847325 [NCIt concept]
- Mobinitinib [NCIt concept]
- Multikinase Inhibitor AT9283 [NCIt concept]
- Tinengotinib [NCIt concept]
- Tozasertib [NCIt concept]
- Tozasertib Lactate [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Aurora A Signaling Pathway [NCIt concept]
- Aurora B Signaling Pathway [NCIt concept]
- Aurora Kinase Signaling Pathway [NCIt concept]
- Mitotic Spindle Regulation Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- PLK1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Anaphase [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Telophase [NCIt concept]
is_target
- Alisertib [NCIt concept]
- Alisertib Sodium [NCIt concept]
- Aurora A Kinase Inhibitor JAB-2485 [NCIt concept]
- Aurora A Kinase Inhibitor LY3295668 [NCIt concept]
- Aurora A Kinase Inhibitor LY3295668 Erbumine [NCIt concept]
- Aurora A Kinase Inhibitor MK5108 [NCIt concept]
- Aurora A Kinase Inhibitor VIC-1911 [NCIt concept]
- Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076 [NCIt concept]
- Aurora Kinase Inhibitor AMG 900 [NCIt concept]
- Aurora Kinase Inhibitor MLN8054 [NCIt concept]
- Aurora Kinase Inhibitor PF-03814735 [NCIt concept]
- Aurora Kinase Inhibitor SNS-314 [NCIt concept]
- Aurora Kinase Inhibitor TTP607 [NCIt concept]
- Aurora Kinase/VEGFR2 Inhibitor CYC116 [NCIt concept]
- Cenisertib [NCIt concept]
- Danusertib [NCIt concept]
- FLT3/ABL/Aurora Kinase Inhibitor KW-2449 [NCIt concept]
- Ilorasertib [NCIt concept]
- Multikinase Inhibitor AT9283 [NCIt concept]
- Polo-like Kinase 1 Inhibitor GSK461364 [NCIt concept]
- Polo-like Kinase 1 Inhibitor MK1496 [NCIt concept]
- Rigosertib Sodium [NCIt concept]
- Tinengotinib [NCIt concept]
- Tozasertib [NCIt concept]
- Tozasertib Lactate [NCIt concept]

Keyword's position in hierarchy(ies) :

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