NCIt definition : A small-molecule pan-Aurora kinase inhibitor with potential antineoplastic activity.
Aurora kinase inhibitor TTP607 selectively binds to and inhibits Aurora kinases A,
B and C, which may result in the disruption of the assembly of the mitotic spindle
apparatus, disruption of chromosome segregation, and inhibition of cellular division
and proliferation in Aurora kinase-overexpressing tumor cells. Aurora kinases A, B
and C, are serine/threonine kinases that play essential roles in mitotic checkpoint
control and are overexpressed by a wide variety of tumor cell types.;
Semantic type(s)